Genuflection Genuflection is reserved for: the Most Blessed Sacrament the Holy Cross from the solemn adoration during the liturgical celebration on Good Friday until the beginning of the Easter Vigil. If the tabernacle is in the sanctuary: Ministers genuflect when they approach the altar and when they depart from it, but not during the celebration of Mass itself. ( The Mass begins with the entrance chant/song ) Else (if the tabernacle is not in the sanctuary): Ministers who pass before the Most Blessed Sacrament genuflect, unless they are moving in procession. Therefore: Non-ministers genuflect in adoration to the Most Blessed Sacrament always . A lay person going to the restroom should genuflect before the tabernacle even during Mass because they're not ministers near the sanctuary. During Mass a reader doesn't have to genuflect -- nor bow (see below) -- when approaching the altar area to read. Special case: Ministers carrying the processional cross or candles bow their h...